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STXBP5

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CNCR ontology

functional group PRE POST
ExcitaBility
LgicSignaling
TyrosineKinase
IntraCellular
StructuralPlasticity
NeuroTransmitter
ExoCytosis
EndoCytosis
PeptideNeurotrophin
IntracellularTrafficking
ProteinClustering
CellAdhesion
IonBalance
SynthesisFolding
CellularMetabolism
MiscUnknown
MitoChondrion

Status of annotation

basic untouched started finished
presynaptic untouched started finished
postsynaptic untouched started finished

Please specify the scope of annotation:

presynaptic postsynaptic

Basic criteria

criterion score
Gene product is a known non-synaptic 10  
PMID: comment:    
Gene product is a known mitochondrial 10  
PMID: comment:    
Gene product is enriched in purified brain synaptosomes 3  
PMID: comment:    
Gene product is expressed in brain (Allen brain atlas, ISH data in papers, other sources) (1) 1  
PMID: comment:    

Presynaptic criteria

criterion score
Activation of the gene product (e.g. receptor) or blockade thereof directly modulates secretion in synapses 5  
PMID: comment:    
Gene product is enriched in purified synaptic vesicle fraction 5  
PMID: comment:    
Nullmutation produces a secretion phenotype in synapses 5  
PMID: comment:    
Gene product is localized in presynaptic compartment with Immuno-EM 5  
PMID: comment:    
Overexpression produces a secretion phenotype in synapses 4  
PMID: comment:    
Null mutation produces a secretion phenotype in secretory cells and gene is expressed in the human brain 4  
PMID: comment:    
Gene product co-localizes with presynaptic marker using high-resolution light-microscopy 3  
PMID: comment:    
Gene product binds specifically to established presynaptic gene product (score >= 5) 1  
PMID: comment:    
Gene is homologous to established presynaptic gene (score >= 5) 0  
PMID: comment:    

Postsynaptic criteria

criterion score
Activation of the gene product (e.g. receptor) or blockade thereof directly modulates postsynaptic basic function/plasticity events 5  
PMID: comment:    
Gene product is localized in postsynaptic compartment with Immuno-EM 5  
PMID: comment:    
Gene product is enriched in purified PSD fraction 5  
PMID: comment:    
Overexpression produces a 'postsynaptic phenotype' (to be made more specific) in synapses 4  
PMID: comment:    
Nullmutation produces a 'postsynaptic phenotype' (to be made more specific) in synapses 4  
PMID: comment:    
Gene product co-localizes with prostsynaptic marker (PSD-95, SAP120. AKAP, etc) using high-resolution light-microscopy 3  
PMID: comment:    
Gene product binds specifically to established postsynaptic gene gene product (score >= 5) 1  
PMID: comment:    
Gene is homologous to established postsynaptic gene (score >= 5) 0  
PMID: comment:    


show history

History

Date User action
CncrGeneAnnotationUser 2010-03-12 08:46:18 activated criterion #7
CncrGeneAnnotationUser 2010-03-12 08:46:14 activated criterion #4
CncrGeneAnnotationUser 2010-03-12 08:46:00 activated criterion #9
CncrGeneAnnotationUser 2010-03-12 08:45:23 activated functional group #7 for pre-synaptic

Topic revision: r2 - 2010-03-12 - 07:47:50 - CncrGeneAnnotationUser
 
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