Difference: Stxbp5 (1 vs. 2)

Revision 22010-03-12 - Main.CncrGeneAnnotationUser

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META TOPICPARENT	name="WebHome"

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STXBP5

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CNCR ontology

functional group	PRE	POST
ExcitaBility
LgicSignaling
TyrosineKinase
IntraCellular
StructuralPlasticity
NeuroTransmitter
ExoCytosis
EndoCytosis
PeptideNeurotrophin
IntracellularTrafficking
ProteinClustering
CellAdhesion
IonBalance
SynthesisFolding
CellularMetabolism
MiscUnknown
MitoChondrion

Status of annotation

Please specify the scope of annotation:

presynaptic postsynaptic

Basic criteria

	criterion	score	<-- -->
	Gene product is a known non-synaptic	10
	PMID: comment:
	Gene product is a known mitochondrial	10
	PMID: comment:
	Gene product is enriched in purified brain synaptosomes	3
	PMID: comment:
	Gene product is expressed in brain (Allen brain atlas, ISH data in papers, other sources) (1)	1
	PMID: comment:

Presynaptic criteria

	criterion	score
	Activation of the gene product (e.g. receptor) or blockade thereof directly modulates secretion in synapses	5
	PMID: comment:
	Gene product is enriched in purified synaptic vesicle fraction	5
	PMID: comment:
	Nullmutation produces a secretion phenotype in synapses	5
	PMID: comment:
	Gene product is localized in presynaptic compartment with Immuno-EM	5
	PMID: comment:
	Overexpression produces a secretion phenotype in synapses	4
	PMID: comment:
	Null mutation produces a secretion phenotype in secretory cells and gene is expressed in the human brain	4
	PMID: comment:
	Gene product co-localizes with presynaptic marker using high-resolution light-microscopy	3
	PMID: comment:
	Gene product binds specifically to established presynaptic gene product (score >= 5)	1
	PMID: comment:
	Gene is homologous to established presynaptic gene (score >= 5)	0
	PMID: comment:

Postsynaptic criteria

	criterion	score
	Activation of the gene product (e.g. receptor) or blockade thereof directly modulates postsynaptic basic function/plasticity events	5
	PMID: comment:
	Gene product is localized in postsynaptic compartment with Immuno-EM	5
	PMID: comment:
	Gene product is enriched in purified PSD fraction	5
	PMID: comment:
	Overexpression produces a 'postsynaptic phenotype' (to be made more specific) in synapses	4
	PMID: comment:
	Nullmutation produces a 'postsynaptic phenotype' (to be made more specific) in synapses	4
	PMID: comment:
	Gene product co-localizes with prostsynaptic marker (PSD-95, SAP120. AKAP, etc) using high-resolution light-microscopy	3
	PMID: comment:
	Gene product binds specifically to established postsynaptic gene gene product (score >= 5)	1
	PMID: comment:
	Gene is homologous to established postsynaptic gene (score >= 5)	0
	PMID: comment:

show history

History

Date	User	action
CncrGeneAnnotationUser	2010-03-12 08:46:18	activated criterion #7
CncrGeneAnnotationUser	2010-03-12 08:46:14	activated criterion #4
CncrGeneAnnotationUser	2010-03-12 08:46:00	activated criterion #9
CncrGeneAnnotationUser	2010-03-12 08:45:23	activated functional group #7 for pre-synaptic

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Deleted:

<
<

META PREFERENCE	name="GENEID" title="GENEID" type="Set" value="%25DATABASE_SQL%7bdescription=%22SynWiki%22 sql=%22SELECT id FROM all_genes WHERE wiki_name = %27%25TOPIC%25%27%22 format=%22$id%22%7d%25"

Added:

>
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META PREFERENCE	name="GENEID" title="GENEID" type="Set" value="%25DATABASE_SQL%7bdescription=%22SynWiki%22 sql=%22SELECT id FROM all_genes WHERE wiki_name = '%25TOPIC%25'%22 format=%22$id%22%7d%25"

Revision 12010-03-12 - Main.CncrGeneAnnotationUser

Line: 1 to 1

Added:

>
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META TOPICPARENT	name="WebHome"

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STXBP5

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Error GeneAnnotationtablePlugin .pm: gene info not retrieved for

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<-- Show annotation form

 
-->

CNCR ontology

functional group	PRE	POST
ExcitaBility
LgicSignaling
TyrosineKinase
IntraCellular
StructuralPlasticity
NeuroTransmitter
ExoCytosis
EndoCytosis
PeptideNeurotrophin
IntracellularTrafficking
ProteinClustering
CellAdhesion
IonBalance
SynthesisFolding
CellularMetabolism
MiscUnknown
MitoChondrion

Status of annotation

Please specify the scope of annotation:

presynaptic postsynaptic

Basic criteria

	criterion	score
	Gene product is a known non-synaptic	10
	PMID: comment:
	Gene product is a known mitochondrial	10
	PMID: comment:
	Gene product is enriched in purified brain synaptosomes	3
	PMID: comment:
	Gene product is expressed in brain (Allen brain atlas, ISH data in papers, other sources) (1)	1
	PMID: comment:

Presynaptic criteria

	criterion	score
	Activation of the gene product (e.g. receptor) or blockade thereof directly modulates secretion in synapses	5
	PMID: comment:
	Gene product is enriched in purified synaptic vesicle fraction	5
	PMID: comment:
	Nullmutation produces a secretion phenotype in synapses	5
	PMID: comment:
	Gene product is localized in presynaptic compartment with Immuno-EM	5
	PMID: comment:
	Overexpression produces a secretion phenotype in synapses	4
	PMID: comment:
	Null mutation produces a secretion phenotype in secretory cells and gene is expressed in the human brain	4
	PMID: comment:
	Gene product co-localizes with presynaptic marker using high-resolution light-microscopy	3
	PMID: comment:
	Gene product binds specifically to established presynaptic gene product (score >= 5)	1
	PMID: comment:
	Gene is homologous to established presynaptic gene (score >= 5)	0
	PMID: comment:

Postsynaptic criteria

	criterion	score
	Activation of the gene product (e.g. receptor) or blockade thereof directly modulates postsynaptic basic function/plasticity events	5
	PMID: comment:
	Gene product is localized in postsynaptic compartment with Immuno-EM	5
	PMID: comment:
	Gene product is enriched in purified PSD fraction	5
	PMID: comment:
	Overexpression produces a 'postsynaptic phenotype' (to be made more specific) in synapses	4
	PMID: comment:
	Nullmutation produces a 'postsynaptic phenotype' (to be made more specific) in synapses	4
	PMID: comment:
	Gene product co-localizes with prostsynaptic marker (PSD-95, SAP120. AKAP, etc) using high-resolution light-microscopy	3
	PMID: comment:
	Gene product binds specifically to established postsynaptic gene gene product (score >= 5)	1
	PMID: comment:
	Gene is homologous to established postsynaptic gene (score >= 5)	0
	PMID: comment:

show history

History

Date	User	action
CncrGeneAnnotationUser	2010-03-12 08:46:18	activated criterion #7
CncrGeneAnnotationUser	2010-03-12 08:46:14	activated criterion #4
CncrGeneAnnotationUser	2010-03-12 08:46:00	activated criterion #9
CncrGeneAnnotationUser	2010-03-12 08:45:23	activated functional group #7 for pre-synaptic

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<-- paths to icons are stored in a hidden so that javascript can access them -->

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META PREFERENCE	name="GENEID" title="GENEID" type="Set" value="%25DATABASE_SQL%7bdescription=%22SynWiki%22 sql=%22SELECT id FROM all_genes WHERE wiki_name = %27%25TOPIC%25%27%22 format=%22$id%22%7d%25"

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